Question

Isoelectric Point of Histones Histones are proteins found in eukaryotic cell nuclei, tightly bound to DNA, which has many phosphate groups. The pI of histones is very high, about 10.8. What amino acid residues must be present in relatively large numbers in histones? In what way do these residues contribute to the strong binding of histones to DNA?

Answer 1

Answer:

Histones have a greater proportion of the amino acids lysine and arginine, they are basic amino acids that give the basic pH and positive charge to the histones and make it easier for them to bind with negatively charged DNA phosphate groups.