Question

The GFP fusion with Sec61 localizes in a pattern that is consistent with the endoplasmic reticulum. In contrast, Sec33 localizes in the Golgi compartment.Although both Sec61 and Sec33 are both involved in secretion, do their localization patterns suggest that they have different roles? Why?

Answer 1

Answer:

The endomembrane system helps in the protein transport, processing and secretion of protein to the different target. The endomembrane system is absent in prokaryotes.

The localization pattern of sec 61 and sec 63 determines the different roles. The protein processing starts in the endoplasmic reticulum and moves to the golgi. If sec 61 is present in ER, this plays an important role in translocation. If sec 33 is present in golgi it might have a role in processing or transport of protein.