Answer: inefficient oxygen transportation
Explanation: sickle cell disease is a genetic disorder in which the haemoglobin is mutated. Haemoglobin is a molecule in the red blood cells that transports oxygen to the cells throughout the body. This mutation of the haemoglobin causes the red blood cells to to have a sickle shape. The abnormal haemoglobin has low affinity for oxygen binding thereby resulting in inefficient transports of oxygen to the cells.
