Question

To reduce the chances of graft rejection, multiple compatibility tests are performed. However, the recipient is still at a risk of rejecting the graft. What other measures must be taken to ensure the proper functioning of the graft?

Answer 1

Answer:

(a) Immuno-suppressive drug therapy may be used to promote acceptance of the graft.

(b) Use of antibiotics and interferons in case infection occurs in the body of the recipient when immune system is suppressed because of immuno-suppressive drug therapy.

Explanation:

Immuno-supressive drug therapy involves administration of drugs to restrict inhibition of T cells.

Following drugs may be used in such therapy:

(1) Glucocorticoids and corticosteroids: These drugs are helpful in down regulation of GPCR signaling as a result of which prostaglandins are not synthesized.

(2) Cyclosporin - A: It leads to the blockage of activation of T lymphocytes.

(3) Rapamycin: It leads to the inhibition of cellular translation as a result of which immune cells do not get activated.