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31-01-2020
Chemistry

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What can be the problems encountered while using magnesium stearate as a lubricant with poorly soluble drug in hard gelatin capsules?

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opeyemimakinde opeyemimakinde

02-02-2020

Answer:

The answer is explained below:

Explanation:

Magnesium stearate is primarily used as a lubricant and as anti-adherent and glidant. This occurs as plate-like crystals staked like a deck of cards.

The use of magnesium stearate causes compression and dissolution problems.

And because stearates are alkaline in reaction, it can not be used with some acidic drugs.

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