Question

The EGF receptor is a protein that is typically embedded in the cellular membrane. Scientists are able to make EGFR in vitro, or outside of the cell, by combining EGFR mRNA with ribosomes and amino acids. However, when this nee protein is introduced to cells, it does not properly localize to the membrane. Which of the following is the most likely explanantion for this observation?

a. the laboratory synthesized EGFR is missing the N terminal portion of the protein

b. because the RGFR was produced synthetically, the amino acid sequence was not correct

c.because the in vitro EGFR did nit travel through the Golgi it was not properly tagged with the molecular modifications needed yo localize to the membrane

d.in vitro synthesis caused degradadtion of the EGFR by cellular ribosomes

Answer 1

Answer:

The correct answer is option c. "because the in vitro EGFR did not travel through the Golgi it was not properly tagged with the molecular modifications needed to localize to the membrane".

Explanation:

The epidermal growth factor receptor (EGFR) protein localization into the cellular membrane is a highly regulated process since the transmembrane part of the protein is very hydrophobic. The EGFR needs to go trough a series of post translational modifications in the Golgi apparatus, including glycosylation and subsequent folding processes. The EGFR synthesized outside the cells did not travel through the Golgi apparatus, therefore it does not go trough the post translational modifications and could not properly localize to the membrane.

Answer 2

The correct answer is C. Because the in vitro EGFR did not travel through the Golgi, it was not properly tagged with the molecular modifications needed to localize to the membrane.

The following information should be considered:

• The proteins should be distributed based on their function.
• Some of the proteins could go to lysosomes or to the plasma membrane (in the case of receptors).
• But, it is needed that Golgi tags specific amino acids of the proteins in order to deliver them to the correct location.

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