Answer:
syphilis
Explanation:
The first significant supporting evidence for a biological cause of a mental disorder was the 19th century discovery that the psychotic disorder called general paresis was caused by the same bacterial microorganism that causes syphilis.
General paresis is a severe neuropsychiatric disorder that is evident in the late stage of syphilis caused by the bacteria Treponema pallidum. Untreated syphilis advances to neurosyphilis (general paresis) which a nervous disorder that affects the spinal cord and the brain, causing brain damage. Symptoms of general paresis includes; Language problems, such as saying or writing words incorrectly, Decreased mental function, such as problems thinking and with judgment.