Answer:
B. sudden muscle weakness
Explanation:
Myasthenia gravis is an autoimmune disease in which communication between the nerves and muscles is affected, producing episodes of muscle weakness.
The cholinergic properties of neostigmine are based on its inhibitory effect on cholinesterase, which stabilizes acetylcholine, whose action is enhanced and prolonged. At the system level digestive and genitourinary, as well as other smooth muscle organs, neostigmine causes contractions and increased peristalsis. Neostigmine neutralizes blockage neuromuscular disorders induced by curare myorelaxants and preparations of the same type (i.e., non-depolarizing) but synergistically interacts with depolarizing myorelaxants.
As with other cholinergics, overdosage with neostigmine may cause cholinergic crisis characterized by marked muscle weakness (or increase of this symptom in myasthenics). If the condition is not identified, there is a risk of death due to respiratory muscle paralysis. Bradycardia, or paradoxically, tachycardia may also occur.
