DNA polymerase has multiple mechanisms for editing and error correction, whereas the capacity for error correction in RNA polymerases seems to be quite limited. However, like a DNA mutation, an RNA polymerase error in transcription can cause production of a mutated protein. The limited error correction of RNA polymerase seems to be inconsistent with the potentially serious consequence of producing a protein with an altered amino acid sequence.A) Defective proteins are often degraded quickly, making their effects temporary. B) Single amino acid substitutions caused by errors in mRNA transcription would not affect protein function. C) Unlike DNA mutations, mRNA transcripts have short half-lives and are not inherited across many generations.D) Degradation of defective proteins activates mRNA repair pathways E) RNA polymerases synthesize many transcripts per gene, so only a small fraction of RNA transcripts would have errors. F) ch mRNA molecule is only translated once and then degraded.

A recent publication (J Phys Condens Matter. 2013. 18;25(37):374104.) provided the information on this matter. According to researcher RNA polymerase have ability to backtrack and translocate the error on both RNA transcript and DNA template. By doing so RNA polymerase cleave the defective part on RNA transcriptome by the process called proofreading. While proofreading contribute in accuracy of transcription but on contrary it also slower the process of transcription.