Fill in the blanks:1. Enzymes are ____________ whose three-dimensional shape is dependent upon environmental variables, including temperature. 2. Enzymes function most efficiently at ____________ temperatures. 3. Temperature increases caused by fever result in ____________ efficient enzyme activity and enzymes are able to make ____________ product in a given period of time. 4. This occurs because increased ____________ energy of molecules enhances substrate and enzyme contact. 5. Severe increases in temperature ____________ the bonds that hold an enzyme's shape. 6. The enzyme subsequently ____________ , permanently ____________ function.