How should the nutritionist explain why fats cannot be directly converted into carbohydrates?

A. Glucose can be created from pyruvate by gluconeogenesis. However, pyruvate generated from fats occurs via the citric acid cycle. Because carbons from fats must enter the citric acid cycle as acetyl CoA first, fats can only indirectly become carbohydrates.
B. During gluconeogenesis, glucose is created from oxaloacetate. However, oxaloacetate generated from fats occurs via the citric acid cycle. Because carbons from fats must enter the citric acid cycle as acetyl CoA first, fats can only indirectly become carbohydrates.
C. Glucose can be created from pyruvate via gluconeogenesis, and fats enter the citric acid cycle as acetyl CoA. However, any acetyl CoA entering the citric acid cycle must be released as CO 2 . Thus, fats cannot be used for synthesis of carbohydrates.
D. The concentration of various intermediates control the activity of metabolic enzymes. Although oxaloacetate is converted into glucose via gluconeogenesis, pyruvate carboxylase is inhibited by oxaloacetate concentrations in the fasting state.

Question

18-12-2019
Chemistry

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How should the nutritionist explain why fats cannot be directly converted into carbohydrates?

A. Glucose can be created from pyruvate by gluconeogenesis. However, pyruvate generated from fats occurs via the citric acid cycle. Because carbons from fats must enter the citric acid cycle as acetyl CoA first, fats can only indirectly become carbohydrates.
B. During gluconeogenesis, glucose is created from oxaloacetate. However, oxaloacetate generated from fats occurs via the citric acid cycle. Because carbons from fats must enter the citric acid cycle as acetyl CoA first, fats can only indirectly become carbohydrates.
C. Glucose can be created from pyruvate via gluconeogenesis, and fats enter the citric acid cycle as acetyl CoA. However, any acetyl CoA entering the citric acid cycle must be released as CO 2 . Thus, fats cannot be used for synthesis of carbohydrates.
D. The concentration of various intermediates control the activity of metabolic enzymes. Although oxaloacetate is converted into glucose via gluconeogenesis, pyruvate carboxylase is inhibited by oxaloacetate concentrations in the fasting state.

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keziasynergy keziasynergy · Answer 1 · 2019-12-31T14:27:25+01:00

Fats cannot be directly converted into carbohydrates during gluconeogenesis, glucose is created from oxaloacetate. However, oxaloacetate generated from fats occurs via the citric acid cycle. Because carbons from fats must enter the citric acid cycle as acetyl CoA first, fats can only indirectly become carbohydrates.

Option B

Explanation:

Gluconeogenesis is the process by which glucose is produced in body from non carbohydrate sources like fat, amino acids etc. This process involves the conversion of each and every product into oxaloacetate and then conversion of oxaloacetate into pyruvate and then the reverse process of Glycolysis is followed.

The concentration of oxaloacetate and ADP maintains the process. An increased amount of both of them supports the gluconeogenesis. But all products must undergo citric acid cycle to get converted into oxaloacetate. So fats are indirectly converted into glucose.