Question

A series of enzymes catalyze the reactions in the metabolic pathway X → Y → Z → A. Product A binds to the enzyme that converts X to Y at a position remote from its active site. This binding decreases the activity of the enzyme. With respect to the enzyme that converts X to Y, substance A functions as ________.
a. an intermediate
b. a competitive inhibitor
c. an allosteric inhibitor
d. the substrate

Answer 1

Answer:

The correct answer will be option-C

Explanation:

In the given question, product A can bind to the enzyme which can convert X to Y.

This product A can act as a non-competitive inhibitor which can attach to the site away from the active site. These compounds are known as allosteric inhibitors.

The allosteric inhibitors bind to the enzyme away from the active site and change the conformation of the protein which changes the conformation of the active site which prevent enzyme bind the substrate.

Thus, Option-C is the correct answer.

Answer 2

With respect to the enzyme that converts X to Y, substance A functions as an ALLOSTERIC INHIBITOR (Option c).

An allosteric inhibitor is a molecule that binds to the enzyme at a site other than the active site (i.e., the allosteric site), thereby decreasing the velocity of a chemical reaction.

Allosteric inhibition is a type of noncompetitive inhibition because the substrate can still bind to the enzyme.

For example, ATP acts as an allosteric inhibitor during cellular respiration. When ATP levels are high, this molecule binds to the phosphofructokinase enzyme in order to slow down the conversion of ADP to ATP.

In conclusion, in this case, substance A functions as an ALLOSTERIC INHIBITOR (Option c).

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