Question

If a sarcomere's troponin molecules are damaged, what will most likely happen?

The sarcomere will break down.

The sarcomere will not be able to contract.

The sarcomere will have uncontrolled muscle contractions.

The sarcomere will die.

Answer 1

The sarcomere will have uncontrolled muscle contractions.

Troponin blocks myosin-binding sites in the tropomyosin of the actin. If the troponin is damages, the myosin-binding sites will be exposed and myosin heads (of the myosin fiber) will be able to form cross-bridges with the actin even when not required.

Explanation:

This means the sarcomere will contract even when not required or expected hence resulting in symptoms like muscle spasms. Usually, troponin molecules exposes the myosin-binding sites on the tropomyosin upon binding of Ca²⁺ ions. These Ca²⁺ are usually released by the sarcoplasmic reticulum upon impulse from the inverted nerve.

Learn More:

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