See Hint Motor neuron degeneration occurs in several diseases and leads to loss of muscle control. One form of motor neuron degeneration was found to have defects in retrograde transport (backward transport to cell body, in blue below) that were caused by mutations in a gene that codes for a particular protein. What protein, when mutated, would inhibit backward, but not outward, transport along axon microtubules
Dynein, when mutated inhibit backward transport in the axon microtubule since Dynein is the cytoplasmic protein responsible for backward transport in the axon microtubule.