Question

Aminoglycosides A) interfere with elongation of peptidoglycan. B) are metabolic analogs of PABA and block folic acid synthesis. C) attach to the 30S ribosomal subunit and disrupt protein synthesis. D) damage cell membranes. E) block peptidases that cross-link glycan molecules.

Answer 1

Answer:

The correct answer is C) attach to the 30S ribosomal subunit and disrupt protein synthesis.

Explanation:

Aminoglycosides are the bactericidal drug which kills the bacteria by stopping the protein synthesis in bacteria. This drug binds to the 30S subunit of bacterial ribosome and cause the misreading of the codon sequence present on mRNA.

This misreading of the mRNA sequence results in the incorporation of the different and wrong amino acids in the polypeptide chain which disrupts protein synthesis. As only bacteria, not humans have 30S ribosomal subunit therefore it does not affect human cells.

So the correct answer is C) attach to the 30S ribosomal subunit and disrupt protein synthesis.