Question

Sickle cell disease provides an example for which principle of molecular genetics?


A. A point mutation always causes a significant change in phenotype.

B. A point mutation always causes a change to an amino acid sequence, which may affect phenotype.

C. A significant change in phenotype may cause a genetic mutation.

D. A change to one amino acid in a protein may cause a significant change in phenotype.


NEVERMIND THE ANSWER IS D.

Answer 1

Answer:

The correct answer is D a change to one amino acid in a protein may cause a significant change in the phenotype.

Explanation:

Sickle cell anemia is caused by the replacement of 6th amino acid in the beta chain of hemoglobin that is glutamic acid by valine.

   glutamic acid is a hydrophilic amino acid that is being replaced by a hydrophobic amino acid known as valine.

   As a result the red blood cells  appear as insoluble aggregates which which ultimately result in the sickling of Red blood cells.That"s why this disease is named as sickle cell anemia.

Answer 2

D. A change to one amino acid in a protein may cause a significant change in phenotype.

Mutation

• A mutation is a change in the nucleotide sequence of an organism's, virus's, or extrachromosomal DNA's genome.
• Sickle cell disease exemplifies the molecular genetics theory that argues that D. A change to one amino acid in a protein may cause a significant change in phenotype.
• Some mutations, known as silent mutations, do not result in changes to the amino acid sequence of the encoded protein.
• Other mutations produce erroneous protein products. Mutations can add new alleles into an organism population, increasing genetic variety.

Find out more information about mutation here:

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