Question

Which type of mutation causes sickle cell anemia?
a. silent
b. missense
c. insertion
d. frameshift

Answer 1

Ans. (b). missense.

Sickle cell anemia is an inherited blood disorder, due to defect in oxygen-transporting protein, hemoglobin. It is caused by a mutation in a gene that codes for hemoglobin that substitutes GAG codon (that codes for glutamic acid) with codon GUG (that codes for valine).

It is known as a missense mutation, which leads to formation of a non-functional or defected protein (hemoglobin). The defected hemoglobin gets polymerized and forms fibers that give sickle-shape to the red blood cells.

Thus, the correct answer is option (b).

Answer 2

The type of mutation that causes sickle cell anemia is called missense. That is option B

What is mutation?

Mutation is defined as the alteration that occurs in the gene of an organism which leads to defective formation in the organism.

Sickel cell anemia occurs when there is missense mutation at a single point in their DNA.

Therefore, the type of mutation that causes sickle cell anemia is called missense.

Learn more about anemia here:

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