In the story of righteous crane, Yaksha asked a lot of questions about the universe to Yudhishthira such as : who make the sun rises to the sky ?
In the present time, we could alter the question to the current scientific mysteries, such as :
- What happen on the other end of the Black Hole ?
- Is big bang theory true ?
- Is there any other civilization in the universe other than human ?
Hope this helps
