Answer:
The correct answer is c) directly binding to heme Fe in the oxygen binding site of the hemoglobin.
Explanation:
Carbon dioxide is the waste product of cellular respiration.Carbon dioxide bind to hemoglobin to form carbaminohemoglobin in which the hemoglobin exist as T state or Tensed state.
Carbon dioxide interact with the oxygen binding site of hemoglobin thus decreasing the affinity of hemoglobin for oxygen.