Answer: A, B, C, D
Explanation: 1. The Tc recognizes the infected host cell
2. The Tc interacts with epitope presented by MHC-I on the dendritic cell
3. The Tc secretes perforin and granzyme, causing apoptosis
4. The helper T cell activates the Tc cell
Cell-mediated immunity is mediated by T lymphocytes. They originate in the bone marrow and mature in the thymus. T cell interact with other cells via its T cell receptor. (TCR). It can only interact with antigenic peptides bound to the Class I MHC molecules on the surface of antigen presenting cells. (APC).
When a TCR of a naïve T cell interacts with and antigen which presents the Class I MHC molecules it gets activated and undergoes differentiation and proliferation which is also known as clonal selection.
There exist two types of T cells
1. Effector or Helper T cells
2. Memory T cells
Cell-mediated responses has both innate and specific immune components. Among the common innate components is the antigen-presenting cell (APC), which interacts with T helper cells to initiate the immune response. After the recognition of the antigen takes places the Tc interacts with epitope presented by MHC-I on the dendritic cell
In addition to granzymes and perforin, T cells are able to produce granulyson and lymphotoxin.
