Which of the following help(s) to stabilize mRNA by inhibiting its degradation? a. introns b. spliceosomes c. RNA polymerase d. TATA box e. 5' cap and poly (A) tail.

Explanation: After transcription, the mRNA must be stabilize by inhibiting its degradation to go out the nucleus to the cytoplasm, to be translated by ribosomes. To do that, mRNA is modified in both ends: a methyl-guanosine cap at 5' end and a poly adenine tail (poly A) at 3' end. These modifications prevent its degradation by RNases because they can't recognize the modified RNA.

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genewho genewho · Answer 2 · 2021-12-14T17:56:06+01:00

To stabilize mRNA by inhibiting its degradation is achieved by adding a bound guanine nucleotide that is called 5 'cap and poly (A) tail.

The transcription of the RNA molecule generally begins with an Adenine or Guanine nucleoside triphosphate, at its 3'OH end the 5 'phosphate end of the next nucleotide is attached.

The addition of 5 'cap and poly (A) tail or protection by the 5'P end of the hn-RNA that, among other things, protects it from its degradation at that end.

This 5 'cap and poly (A) tail consists of the addition of a 7-methylguanosine residue by establishing a triphosphate bond.

This causes the added guanosine to bind in the opposite direction to the rest of the polynucleotide chain.

Therefore, we can conclude that the 5 'phosphate end of the molecule being synthesized must prevent its degradation and is protected by adding 5' cap and poly (A) tail to stabilize mRNA.

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