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Today, many derivatives of penicillin have been developed that inhibit more types of bacteria than the original life-saving drug. Penicillin itself is active against

  • streptococci (including Streptococcus pneumoniae),

  • Listeria, Neisseria gonorrhoeae,

  • Clostridium,

  • Peptococcus,

  • Peptostreptococcus.

However, most staphylococci now are resistant to penicillin.

Other penicillin antibiotics are effective against

  • H. influenzae,

  • E. coli, pneumococci,

  • certain strains of staphylococci,

  • Salmonella,

  • Shigella,

  • Pseudomonas aeruginosa, and

  • many other types of bacteria.

Penicillin antibiotics are used to treat many types of infections caused by susceptible bacteria. They are used to treat infections of the middle ear, sinuses, stomach and intestines, bladder, and kidney. They also are used for treating

  • pneumonia,

  • blood infections (sepsis),

  • uncomplicated gonorrhea,

  • meningitis,

  • endocarditis, and

  • other serious infections.

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