Answer: Kidney Disfunction.
Explanation:
Metoprolol is a medicine which is used alone or with the help of other medicines to treat high blood pressure. High blood pressure add loads to the arteries and heart.
If this medicine is taken for a longer period of time then the blood vessels of heart, kidneys and brain can be hampered. Kidney Dis function is one of the major side effect associated with this medicine.
So, the correct answer is option A