There are 5 prefixes, 5 roots and 5 suffixes, so it is possible to find the answer by matching them:
Malnutrition: It is a lack of nourishment (food).
Interactive: It is something able to interact.
Transcontinental: It is something between or across continents.
Contraindicate: Suggests that a drug or medicine should not be used for the sickness in question.
Inexorable: It is somebody impossible to persuade