Question

What of the following is the least preferable way to refuse when someone offers you drugs at a party

Answer 1

Just say either like someone offers you drugs to say oh no thanks I’m laying low today or something like I already have a drug sorry but just pretend that you have something so they won’t get all like you know something like I don’t know if you understand me just pretend like you have some or you’re like into that and like just leave.

Answer 2

If the question means: "Which option is the worst way to say no to drugs":

The worst way is to say yes, but tell yourself that you are not actually going to do it. That would  be the worst way to do it. What if you get tempted, or worse, someone superior finds it on you and accuses you of taking drugs.