You would just distribute.
6 times 1= 6
6 times -x= -6x
So that would come together and be 6-6x.You would just do the same for the next one.
-5 times 3= -15
-5 times 2z= -10z
Now, all of that together is 6-6x-15+10z. Finally, you would just combine like terms.
6-15= -9
Your answer would be -9-6x+10z or it could be in a different order, but it's still correct.