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Chromatin condensation begins during prophase (2) and chromosomes become visible. Chromosomes remain condensed throughout the various stages of mitosis (2-5). ... However, when eukaryotic cells are not dividing — a stage called interphase — the chromatin within their chromosomes is less tightly packed.



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Chromosomes are not condensed during all stages all the cell cycle because the cell needs to replicate its genetic material (DNA) and transcribe different genes during interphase.

  • The cell cycle can be divided into an interphase and a mitotic (M) phase.

  • The interphase can in turn be divided into a Growth 1 (G1) phase, the synthesis (S) phase, and Growth2 (G2) phase.

  • During these three phases (I.e., G1 phase, S phase and G2 phase) the chromosomes can be found in an uncondensed state.

  • During the S phase, the cell replicates its genetic material, whereas during G1 and G2 phases different genes are transcribed to produce different proteins required during cell division.

  • During the first phase of the M phase called Prophase, chromosomes condense in order to prepare for cell division.

In conclusion, chromosomes are not condensed during all stages all the cell cycle because the cell needs to replicate its genetic material (DNA) and transcribe different genes during interphase.

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