The correct option is c. the presence of appropriate receptors on target cells.
Hormones are secreted by the endocrine glands and act as chemical messengers enabling communication between the cells. The hormones have several diverse functions like to maintain homeostasis, regulation in different metabolic processes etc. The hormones are secreted into the extracellular environment from where they diffuse to the bloodstream and are transported by the circulatory system to the target cells. The target cells contain the receptors specific for a particular hormone and is activated either by a lipid soluble or by a water soluble hormone which binds to the cell surface receptors.