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The biggest difference between prokaryotic and eukaryotic is that eukaryotic cells have a nucleus and prokaryotic cells do not.
I would do this in your own words but here is the answer.... Both organisms are composed of cells, the basic unit of life, with each cell surrounded by a cell membrane. The biggest difference between prokaryotes and eukaryotes is that eukaryotes have a nucleus. They also have other membrane structures called organelles.
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