___ a nuisance, but you do at least have ___ wits about you.
You're, your because the first one is possessive and the second one is a contraction for "you are."
You're, you're because both blanks need the contraction for "you are."
You're, your because the first one is a contraction for "you are" and the second one is possessive.
Your, your because they are both possessives.
