Variation in a gene pool comes about by a mutation in the DNA. (However, the mutation must occur in a gametic cell to be passed on to offspring.) Explain how a point mutation may result in a new phenotype, which, in turn, becomes part of the gene pool. How could this new phenotype increase in frequency among the population if it is a mutation? If you need help with this question, look into the mutation that causes blue eyes or lactose tolerance.