Most anaphylactic reactions to penicillin occur when ________.
1) when the drug is administered orally
2) in patients who have already experienced an allergic reaction to the drug
3) in patients with a negative skin test to penicillin allergy
4) when the drug is administered parenterally
5) within minutes after drug administration

i. a, b, and d
ii. b, c, and d
iii. b, d, and e
iv. b and e
v. c, d, and e