In Koob and LeMoal’s transition to the dark side of addiction, there is a progressive down-regulation of activity in the reward system involving _________; and a gradual recruitment of the anti-reward system involving ________?
a. dopamine, GABA & opioids; CRF & norepinephrine
b. CRF & norepinephrine; dopamine, GABA & opioids
c. 5-HT & norepinephrine; dopamine, GABA & opioids
d. dopamine, GABA & opioids; 5-HT & norepinephrine
e. dopamine, 5-HT & opioids; CRF and GABA
