Food can both increase and decrease bioavailability. Below are given several scenarios for food effect. Indicat which situations may INCREASE or DECREASE the bioavailability of drugs. Explain your rational 1. Food with high fat content together with a lipophilic, low solubility drug. 2. A meal that slows the gastric emptying for a drug that is actively absorbed 3. Food that contains organic acids together with drugs absorbed by organic cation transporters 4. Food with high fat content together with drugs that are substrates for the PGP transporter 5. Food that interact with the PGP transporter together with drugs that are substrates for the PGP transporter
