Which of the following statements is true regarding cardiovascular disease and adipose tissue? Please select the single best answer Inflammatory cytokines, synthesized and released by adipose tissue, contribute to the development of cardiovascular disease. Increased synthesis and secretion of PAI-1 in metabolic syndrome contributes to cardiovascular disease by increasing blood pressure. Obesity in metabolic syndrome contributes to the development of cardiovascular disease by increased synthesis and secretion of adiponectin. There is no correlation between the amount of adipose tissue and cardiovascular disease.