part a which of the following would be unlikely to contribute to the substrate specificity of an enzyme? view available hint(s)for part a which of the following would be unlikely to contribute to the substrate specificity of an enzyme? environmental factors such as temperature and ph. a similar shape exists between a pocket on the surface of the enzyme and a functional group on the substrate. a positive charge on the substrate is attracted to a negative charge in the active site of the enzyme. a hydrophobic group on the substrate interacts with several hydrophobic amino acids on the enzyme. the enzyme has the ability to change its configuration in response to the substrate binding.
