cushing's disease is characterized by muscle weakness due to adrenal or pituitary dysfunction. to most effectively treat the disease, it needs to be diagnosed in childhood as early as possible. a study measured the age at onset of symptoms and the age at diagnosis (both in months) for 15 randomly selected children with the disease. the researchers wanted to examine the time gap (difference in age) between the age at onset of symptoms and the age at diagnosis by looking at the difference (age at diagnosis less age at onset). for example, one child was diagnosed at 64 months old and the onset of symptoms was at 24 months old, so the difference in age d