Which of the following statements describes a major difference between meiosis II and mitosis in a diploid animal? Sister chromatids separate in mitosis, and homologous chromosomes separate in meiosis II. Meiosis il occurs in a haploid cell, while mitosis occurs in diploid cells. Crossing over of chromosomes takes place in meiosis 11 Homologous chromosomes align on the metaphase plate in meiosis II.